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We found no significant effect or even tendency toward an effect (PTable 2, regardless of whether these categories were treated as ordered or unordered. Next, by examining response to testosterone treatment at the 300-mg level, as discussed in the "Participants and Methods" section, we found only a slight effect. Looking at the first treatment period only, the changes on psychiatric measures were similar to those found in the primary analysis but yielded lower levels of statistical significance. As with the primary analysis, the difference between testosterone and placebo treatment on the other 4 primary psychological measures was not significant. By comparison, the 50 placebo periods produced no marked, 1 moderate, and 49 minimal responses. Diary scores seemed to be consistent with this classification: manic scores of the 8 moderate or marked responders increased significantly more than those of the 42 minimal responders (median, 6. The latter were Deca Durabolin at baseline and Deca the end of the testosterone period. No comparison yielded a significant difference. Also, none of the 11 individuals reporting a first-degree relative with a major mood disorder were among the 8 testosterone responders. Although diet, exercise, and times of blood drawing were not standardized across participants in this primarily psychiatric study, testosterone treatment produced expected changes on physiological and laboratory test results (Table 3). No serious laboratory abnormalities or adverse medical events occurred during the study. These effects were largely confined to a small group of "responders"but this group proved indistinguishable from "nonresponders" on demographic, psychological, physiological, and laboratory measures. The small number of responders in this analysis raises the possibility of a type II errorfailure to reject the null hypothesis when a true difference exists. Also, the laboratory measures included total but not free testosterone, leaving open the small possibility that responders might have differed on the latter measure. However, such responses may be idiosyncratic and presently unpredictable.

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